Paper Contents
Abstract
Alzheimer disease is a complex neurodegenerative dementing illness. It has become a major public health problem because of its increasing prevalence, long duration, high cost of care, and lack of disease-modifying therapy. Over the past few years, however, remarkable advances have taken place in understanding both the genetic and molecular biology associated with the intracellular processing of amyloid and tau and the changes leading to the pathologic formation of extracellular amyloid plaques and the intraneuronal aggregation of hyper phosphorylated tau into neurofibrillary tangles. Currently available cholinesterase inhibition therapy targets the cognitive symptoms. However, the goal of new therapies under development is halting the pathologic cascade and potentially reversing the course of the disease. If these new therapies are successful, they will represent a remarkable medical advance for patients and the families who care for them.
Copyright
Copyright © 2025 Dr. Manchineni Prasada Rao, Dr. V. Rajini, Dr. Y. Narasimha Rao, P Y V Kameswara Rao. This is an open access article distributed under the Creative Commons Attribution License.
