Paper Contents
Abstract
Around 40-60% of potential drugs in the pharmaceuticals market are lipophilic in nature due to the low aqueous solubility and low permeability and thereby facing problems in their formulation. Their rare-limiting step is the dissolution-rate of the drugs. For BCS class11 drugs which have the therapeutic delivery of lipophilic active moieties receive more attention due to this reason. One of the formulation systems that deal with poor solubility, slow dissolution rate is self-micro emulsifying drug delivery system. The hypothesis between dissolution rate enhancement with SEDDS is the spontaneous formation of the emulsion in the gastrointestinal tract which presents the drug in solubilized from and small size of the formed droplet provide a large interfacial surface area for drugs absorption. Due to small global size the micronano-emulsified drug can easily be absorbed through lymphatic pathways, thereby bypassing the hepatic first-pass effect.in practical use, the lipid formulation range from pure oils to blend which contain a strong proportion of hydrophilic surfactants or co-solvents. This review gives a complete summery of SEEDS which may be a promising approach to effectively overcome the problem of poorly soluble molecules.
Copyright
Copyright © 2024 D.MOUNIKA. This is an open access article distributed under the Creative Commons Attribution License.
