Paper Contents
Abstract
The goal of the current study was to create and describe new colon-specific drug delivery systems based on microspheres that contained insulin for the treatment of diabetes. It was anticipated that colon-specific drug delivery systems based on microspheres would efficiently target bioactive substances and lengthen residence duration. Proteolytic enzymes and the stomach's acidic environment break down insulin very fast. The primary issue is digestion and the absence of a certain peptide carrier system in the stomach, which is why the insulin tablet fantasy has not come to pass. The microsphere core tablets were then made using the direct compression technique and compression coated with a combination of pectin and HPMC. The colonic flora's biodegradation of pectin was the rationale behind its selection. HPMC is said to improve the tablet coat's mechanical strength and aid in preserving its integrity in the gastrointestinal tract's jejunum.
Copyright
Copyright © 2025 Abhishek Payasi. This is an open access article distributed under the Creative Commons Attribution License.
