Paper Contents
Abstract
This study investigates the impact of Paclitaxel-loaded nanoparticles on blood flow, heat transfer, and drug concentration in a stenosed artery using a mathematical modeling approach. The velocity profile is influenced by buoyancy forces, with the Grashof number enhancing flow dynamics, while resistance near the stenosis reduces velocity. The temperature profile reveals the critical role of thermophoresis and Brownian motion in promoting efficient heat dissipation, vital for regulating thermal gradients and improving nanoparticle efficacy. The drug concentration is highest near the stenotic region, ensuring targeted delivery, with enhanced diffusion facilitated by nanoparticle-induced effects. The results highlight the potential of nanotechnology to optimize cardiovascular treatments by improving drug delivery, enhancing thermal management, and reducing restenosis risks. These findings provide a foundation for future experimental validation and patient-specific modeling to advance personalized therapies for arterial diseases.
Copyright
Copyright © 2025 Anuradha Singh1. This is an open access article distributed under the Creative Commons Attribution License.
