Paper Contents
Abstract
The present study focuses on the formulation and evaluation of fast disintegrating tablets (FDTs) of Eletriptan hydrobromide, an antimigraine agent with poor oral bioavailability due to extensive first-pass metabolism. The aim was to develop a formulation that ensures rapid onset of action by enhancing disintegration time and drug release. Various superdisintegrants, including sodium starch glycolate (SSG) and croscarmellose sodium (CCS), were used in different concentrations. Among the formulations developed, formulation F5, containing SSG and CCS, demonstrated optimal results with a disintegration time of less than 15 seconds, meeting all required physicochemical parameters. In vitro drug release studies showed up to 99.7% release, indicating excellent dissolution characteristics. These findings support the potential of FDTs of Eletriptan hydrobromide as a fast-acting, patient-friendly alternative for the effective management of acute migraine attacks.
Copyright
Copyright © 2025 Vishal bhagwan Ambekar . This is an open access article distributed under the Creative Commons Attribution License.
