Paper Contents
Abstract
AbstractIn this present study, floating of Alfuzosin HCL were formulated to improve the gastric retention time and overall bioavailability. Different mucoadhesive polymers like HPMC K200 M, Na CMC, Carbopol 974P, Karaya gum, Chitosan and Xanthan gum were selected to formulate the tablets. Various formulations were prepared by using these polymers in different concentration. The pre-compression blend of Alfuzosin HCL mucoadhesive tablets were characterized with respect to angle of repose, bulk density, tapped density, carrs index and hausners ratio and all the results indicated that the blend was having good flow property and hence better compression properties. The swelling studies were peFormed for the formulations and the results depicted that all the formulations have a good swelling index. The drug release studies depicted that the formulations release the drug in first order. So based on the results, formulation F13 was found to be an optimized formulation.Keywords: Mucoadhesive tablets, Alfuzosin HCL, Bioadhesive polymers
Copyright
Copyright © 2025 Pratik Bharat Shinde. This is an open access article distributed under the Creative Commons Attribution License.
