Paper Contents
Abstract
Hot Melt Extrusion (HME) has emerged as a transformative technology in modern drug formulation, offering innovative solutions to long-standing challenges in the pharmaceutical industry. As a solvent-free, continuous manufacturing process, HME enhances the bioavailability of poorly water-soluble drugs through the formation of amorphous solid dispersions and enables the development of advanced dosage forms such as sustained-release tablets, transdermal systems, and implantable devices. Recent advancements in HME include the integration of twin-screw extruders, the co-extrusion of multi-layered drug delivery systems, and the incorporation of 3D printing for personalized medicine.
Copyright
Copyright © 2025 Ms. Revati Pramod Bhopale1. This is an open access article distributed under the Creative Commons Attribution License.
