Paper Contents
Abstract
AbstractBunium persicum (Kala Jeera), commonly known as black cumin, has been traditionally used in various medicinal systems for its potent gastroprotective properties. This review explores its role in digestion and ulcer prevention, emphasizing its pharmacological potential in gastrointestinal health. Bunium persicum contains bioactive compounds such as flavonoids, terpenes, alkaloids, and essential oils, which contribute to its therapeutic effects. The spice enhances digestive enzyme secretion, improves gut motility, and reduces bloating and indigestion. Its carminative and anti-inflammatory properties aid in maintaining gastrointestinal homeostasis.Several studies have highlighted Bunium persicums role in ulcer prevention by inhibiting gastric acid secretion, promoting mucus production, and enhancing mucosal defense mechanisms. The presence of antioxidants such as thymol and cuminaldehyde helps in scavenging free radicals, thereby preventing oxidative stress-induced gastric mucosal damage. Additionally, its antimicrobial properties combat Helicobacter pylori, a key pathogen implicated in peptic ulcer disease. The modulation of inflammatory cytokines and the inhibition of pro-inflammatory pathways further contribute to its gastroprotective action.Preclinical studies have shown that Bunium persicum extracts can significantly reduce ulcer index and gastric lesions in experimental models. The spice's ability to regulate gut microbiota also plays a crucial role in maintaining digestive health. Despite promising results, clinical trials validating its efficacy in humans remain limited. Future research should focus on the standardization of bioactive compounds, dosage optimization, and mechanistic insights into its gastroprotective effects.In conclusion, Bunium persicum holds significant potential as a natural gastroprotective agent. Its ability to enhance digestion and prevent ulcers makes it a valuable candidate for complementary and alternative therapies in gastrointestinal disorders. Further investigations are warranted to establish its clinical relevance and therapeutic applications.Keywords: Bunium persicum, Kala Jeera, gastroprotection, ulcer prevention, digestive health, anti-inflammatory, antioxidant, Helicobacter pylori, gut microbiota
Copyright
Copyright © 2025 Dr. Sanjay Kumar Acharya . This is an open access article distributed under the Creative Commons Attribution License.
