Paper Contents
Abstract
AbstractThe advent of phytosomal drug delivery systems represents a pivotal innovation in botanical extracts, including poor absorption, low membrane permeability, and reduced systemic bioavailability. Phytosomes are generated through molecular complexation between phytoconstituents and phospholipids, particularly phosphatidylcholine, thereby enhancing the lipophilic character and gastrointestinal uptake of hydrophilic molecules. This system not only augments the pharmacological efficacy of bioactives but also confers protection against enzymatic degradation. Substances such as curcumin, silybin, and quercetin exhibit markedly improved bioavailability when delivered via phytosomal formulations compared to conventional extracts.Recent advances in nanotechnology have facilitated the development of next-generation carriers, including nano-phytosomes and stealth-modified phytosomes, which enable site-specific targeting, controlled drug release, and reduced systemic toxicity. Commercial formulations like Siliphos, Meriva, and Greenselect have received regulatory approval and achieved clinical as well as market success. Furthermore, modern fabrication methodssuch as spray-drying and biopolymer-based encapsulationhave substantially enhanced formulation stability and extended product shelf life. Given the rising preference for safer natural therapeutics, phytosomal delivery systems are increasingly recognized as a convergence of traditional herbal medicine and advanced pharmaceutical technologies. Future research will emphasize the design of stimuli-responsive smart phytosomes and patient-tailored phytopharmaceuticals, supporting the paradigm of precision herbal medicine
Copyright
Copyright © 2025 Priyanka Bapu Shinde. This is an open access article distributed under the Creative Commons Attribution License.
