Paper Contents
Abstract
This review focuses on development and validation of UV spectrophotometric method for Trimethopthoprim in pure and marketed formulation. . Trimethoprim is an antibacterial drug with a chemical structure that includes:1). 2,4-diamino pyrimidine moiety 2)1,2,3-trimethoxybenzene moiety 3).A methylene bridge connecting the two moieties . It is useful in the treatment of UTI (Urinary Tract infection). A rapid and sensitive method was developed for the analysis of Trimethoprim in both pure and tablet dosage form. The Methanolic solution of pure drug trimethoprim at room temperature of (25 10C) was measured at a maximum of 285 nm. Under optimum and validated test conditions, Beer's rule was followed within the concentration range of 10 - 60 g ml. He experiment for linearity, accuracy, precision(Intra day& interday precision), Range, detection limits, quantification limits,robustness and ruggedness were performed. The preformulation parameters in terms of Melting point of trimethoprim were studied. The method is desirable for evaluating the quality and effectiveness of pure as well as commercial formulations of this significant pharmaceutical constituents.
Copyright
Copyright © 2025 Mr.Kotkar V.R , Dr.Salve M.T. This is an open access article distributed under the Creative Commons Attribution License.
