Paper Contents
Abstract
Abstract:Inflammatory bowel diseases (IBD) require targeted drug delivery to minimize systemic side effects. This study developed and evaluated prednisolone tablets for colon-targeted delivery using pH-dependent and mucoadhesive approaches. Five formulations were prepared using Eudragit L100, chitosan, and polyethylene oxide. In vitro release studies demonstrated controlled release in simulated colonic conditions (pH 7.4). In vivo pharmacokinetic studies in rats showed significantly higher colon tissue concentrations (p < 0.05) and reduced systemic exposure compared to conventional prednisolone. Colon targeting efficiency was optimized using mucoadhesive formulations, achieving 3.5-fold higher drug concentration in colon tissue. These findings suggest that colon-targeted prednisolone tablets can enhance therapeutic efficacy while minimizing systemic side effects, offering a promising treatment option for IBD patients.Keywords: Colon-targeted drug delivery, Prednisolone, Inflammatory bowel diseases, Controlled release formulations, Mucoadhesive systems.
Copyright
Copyright © 2024 Mr. Prashant Ambadas Kadam Prof. Poonam khade, Dr. Megha Salve. This is an open access article distributed under the Creative Commons Attribution License.
