Paper Contents
Abstract
Mucoadhesive buccal tablets shows significant effect as an advanced drug delivery system due to their capacity to enhance bioavailability, extend drug release, and improve patient compliance. They interact with the mucus layer covering the mucosal epithelial surface, and mucin molecules and prolongs the residence time of the dosage form at the site of application. This leads to increased drug plasma concentrations and therapeutic activity. Bio adhesion is the state in which two materials, at least one of which is of a biological nature, are held together for extend period of time by interfacial forces. Buccal mucosa is the favoured site for both systemic and local drug action.Various mucoadhesive dosage forms have been developed, such as patches, tablets, films, microspheres, and nanoparticles. These dosage forms exhibit prolonged retention time and controlled drug release, leading to enhanced therapeutic efficacy. Mucoadhesive drug delivery systems have been used for the treatment of several local diseases like gastrointestinal disorders, ocular disorders and vaginal infections. In conclusion, mucoadhesive drug delivery systems have proven to be advantageous in enhancing drug plasma concentrations and therapeutic effect. The selection of mucoadhesive polymers, size, and shape of the drug delivery system, and the mechanism of adhesion are critical factors in developing a successful mucoadhesive drug delivery system.Keywords- Buccal tablets, drug delivery systems, mucoadhesion, patient compliance, therapeutic efficacy.
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Copyright © 2025 Kothamasu kanakadurga. This is an open access article distributed under the Creative Commons Attribution License.
