Paper Contents
Abstract
ABSTRACTMucoadhesive buccal tablets represent a promising drug delivery system that allows drugs to be absorbed directly through the buccal mucosa, bypassing the gastrointestinal tract and hepatic first-pass metabolism. This route offers several advantages, including improved bioavailability, rapid onset of action, ease of administration, and enhanced patient compliance. These systems use mucoadhesive polymers such as HPMC, carbopol, chitosan, and sodium alginate to ensure prolonged adhesion to the mucosal surface, allowing sustained drug release.This review focuses on the principles of mucoadhesive, the anatomy of the buccal cavity, and various types of polymers used in buccal tablet formulation. It also discusses formulation approaches, evaluation parameters like mucoadhesive strength and drug release profiles, and current advancements including bilayer tablets and nanoparticle-based systems. Mucoadhesive buccal tablets have shown great potential for delivering both systemic and local therapies, making them an effective and innovative alternative to conventional dosage forms.
Copyright
Copyright © 2025 Chava Bhuvana sri. This is an open access article distributed under the Creative Commons Attribution License.
