Paper Contents
Abstract
Stimuli-responsive polymers (SRPs) are smart macromolecules capable of undergoing conformational, physical, or chemical changes in response to environmental stimuli, including pH, temperature, light, magnetic fields, and specific biochemical signals 15. Over the last decade, SRPs have emerged as pivotal components in advanced drug delivery systems, offering controlled, site-specific, and temporally regulated therapeutic release. This comprehensive review examines the design principles, classification, and mechanistic aspects of SRPs. We discuss their applications in oncology, gene therapy, tissue engineering, ocular delivery, and immunotherapy, highlighting examples of polymer-drug systems under preclinical and clinical evaluation 610. Challenges such as biocompatibility, degradation kinetics, scalability, and regulatory hurdles are critically analyzed. Finally, emerging strategies like multistimuli-responsive systems, smart hydrogels, and nanoparticle-based carriers are explored, offering insights into the future of personalized and precision medicine 1115.
Copyright
Copyright © 2025 Gangolla Tarun Reddy. This is an open access article distributed under the Creative Commons Attribution License.
