Paper Contents
Abstract
Abstract:Antibody-Drug Conjugates (ADCs) represent a promising new class of anticancer therapeutics, showing significant potential for targeted cancer treatment. The rapid advancements in ADC development over the past two decades have been largely enabled by innovative technologies and methodologies. Among these, Click Chemistry has emerged as a valuable tool, facilitating efficient bioconjugation, material science applications, and drug discovery. This review explores the impact of Click Chemistry on ADC synthesis and development, focusing on the most frequently used reactions, including Michael addition, Copper-catalyzed azide-alkyne 3+2 cycloaddition (CuAAC), Strain-promoted azide-alkyne 3+2 cycloaddition (SPAAC), oxime bond formation, hydrazine-iso-Pictet-Spengler ligation (HIPS), and Diels-Alder reactions. Furthermore, the review highlights the application of thiol-based reactions in ADC synthesis.
Copyright
Copyright © 2025 Dherange Sakshi Sanjay . This is an open access article distributed under the Creative Commons Attribution License.
