Paper Contents
Abstract
Tolcapone trilayer matrix tablets featuring mucoadhesive properties were created through direct compression technique, incorporating a central active layer made up of different viscosity grades of HPMC, ethyl cellulose, and Na CMC as release retardants. Barrier layers were created using Eudragit L100-55, guar gum, ethyl cellulose, magnesium stearate, talc, and DCP. The trilayer matrix tablets were assessed for their physicochemical properties, in vitro drug performance, compatibility between the drug and excipients, mucoadhesive characteristics, release kinetics, and in vivo bioavailability. According to the assessment criteria, the drug dissolution characteristics and release order kinetics, formulation HF16 was determined to be the optimized formulation exhibiting mucoadhesive properties. The created drug delivery system achieved drug release rates sustained for 24 hours. The release pattern of the optimized formulation (HF16) was characterized by zero-order kinetics and aligned best with the Higuchi model. FT-IR and DSC analyses confirmed that no chemical interaction occurred between the drug and the excipients utilized in the formulation.
Copyright
Copyright © 2025 Mahesh Ashok Kardule. This is an open access article distributed under the Creative Commons Attribution License.
