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Abstract
ABSTRACTPyridoxine derivative metadoxine has shown great promise as a medicinal agent, especially for the treatment of liver ailments. This article offers a thorough analysis of the pharmacological characteristics of metadoxine, covering its mode of action, recommended uses, and side effects. The paper also discusses the analytical techniques used to quantify metadoxine in a variety of matrices, including biological fluids and pharmaceutical formulations. It is stressed how crucial reliable and precise analytical techniques are for therapeutic medication monitoring, quality assurance, and pharmacokinetic research.Keywords: metadoxine, pharmacological properties, analytical methods, liver diseases, chromatography, mass spectrometry.INTRODUCTIONAlcohol intoxication, both acute and chronic, is treated with metadoxine, often referred to as pyridoxine-pyrrolidone carboxylate. Blood alcohol removal from the body is accelerated by metadoxine. The main conditions for which metadoxine is prescribed are fatty liver disease and alcoholism. Alcohol is better metabolized and liver function is enhanced. The possibility of using it to treat cognitive impairment and ADHD has also been studied. Figure-1:Structure of MetadoxineChemical name: Chemically it is 5-Oxo-L-proline-4, 5-bis (hydroxymethyl)-2- methylpyridin-3-olChemical formula: C13H18N2O6Molecular weight: 298.295 g.mol1Category: Hepatoprotective.Pyridoxine and pyrrolidone carboxylate (PCA) ion pair salts are combined to form metadoxine. Vitamin B6, pyridoxine, is a precursor of coenzymes that include pyridoxal 5'-phosphate (PLP), which prevents acetaldehyde from inactivating adenosine triphosphate (ATP) and speeds up the metabolism of ethanol. Serotonin (5-HT), epinephrine, norepinephrine, and GABA are four major neurotransmitters that are also produced by pyridoxal phosphate-dependent enzymes.
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Copyright © 2024 AFIRIN FARAHANA. This is an open access article distributed under the Creative Commons Attribution License.
