Paper Contents
Abstract
Transdermal drug delivery system (TDDS) is one of the systems lying under the category ofcontrolled drug delivery, in which the aim is to deliver the drug through the skin in apredetermined and controlled rate. It has various advantages, like prolonged therapeutic effect,reduced side-effects, improved bioavailability, better patient compliance and easy termination of drug therapy. The stratum corneum is considered as the rate limiting barrier in transdermalpermeation of most molecules. There are three main routes of drug penetration, which includethe appendageal, transcellular and intercellular routes. Skin age, condition, physicochemicalfactors and environmental factors are some factors that are to be considered while deliveringdrug through this route. Basic components of TDDS include polymer matrix, membrane, drug,penetration enhancers, pressure-sensitive adhesives, backing laminates, release liner, etc.Transdermal patches can be divided into various systems like reservoir system, matrix systemand micro-reservoir system, which are used to incorporate the active ingredients into thecirculatory system via the skin. After preparation of transdermal patches, consistentmethodology are adopted to test the adhesion properties, physicochemical properties, in vitrodrug release studies, in vitro skin permeation studies, skin irritation studies and stability studies. According to the duration of therapy, various drugs are commercially available in the form of transdermal patche.Keywords- Transdermal Drug Delivery System, Routes of Penetration, Factors Affecting Transdermal Drug Delivery, Types of Transdermal Patches, Evaluation of Transdermal Films.
Copyright
Copyright © 2023 Prajakta G. Chavhan. This is an open access article distributed under the Creative Commons Attribution License.
