Paper Contents
Abstract
Oral delivery is the most practical and recommended method of drug delivery due to its ease of use and patient compliance. However, challenges such as poor bioavailability and short gastrointestinal residence times can limit the effectiveness of certain medications. To address these issues, researchers have developed gastroretentive drug delivery systems (GRDDS), which extend the duration of the drug's residence time in the stomach and upper gastrointestinal tract, thereby Improving absorption and therapeutic efficacy. This review discusses various types of GRDDS, including floating, expandable, and bio adhesive systems, and their mechanisms of action. Additionally, it explores the physiological gastric retention-causing factors, the advantages and applications of GRDDS, and the future potential of these systems in improving drug delivery and patient outcomes.
Copyright
Copyright © 2024 Dr. Padmapreetha.J. This is an open access article distributed under the Creative Commons Attribution License.
