Paper Contents
Abstract
The leaves of Cinnamomum zeylanicum have been used in traditional health systems to treat diabetes mellitus. However, the antidiabetic activity of this medicinal plant is not scientifically validated and authenticated. The present study aimed to investigate the in vitro and in vivo anti-diabetic activity of flower crude extract and solvent fractions of Cinnamomum zeylanicum. The in vitro amylase inhibition of the crude extract and solvent fractions of Cinnamomum zeylanicum. Blood glucose lowering activity of 80% Ethanolic crude extract and solvent fraction was studied in animal models: Hypoglycemic mice model, oral glucose loaded mice model, dose-treated Alloxan -induced diabetic mice model. The effect of the crude extract on diabetic lipid profile was studied. The acute toxicity study of Cinnamomum zeylanicum leaves extract did not show mortality in the animals at the limit dose during the observation period. The result of amylase enzyme inhibition activity was found in a dose-dependent manner, the strongest activity was shown by Crude extract fraction (89.60 % inhibition at 1000 gmL) compared to the standard acarbose having 97.19% inhibition at 1000 gmL. The crude extract of Cinnamomum zeylanicum showed significant blood glucose-lowering effect on hypoglycemic mice and oral glucose loaded mice. In Alloxan-induced diabetic mice model, the crude extract fraction significantly decreased the fasting blood glucose level after 14 days of treatment.The result demonstrated the beneficial biochemical effects of Cinnamomum zeylanicum extract by inhibiting amylase improving serum lipid profile levels. The leaves crude extract are effective in lowering blood glucose levels in diabetic and hypoglycemic mice. The claimed traditional use as antidiabetic has scientific ground.
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Copyright © 2024 Shirisha. This is an open access article distributed under the Creative Commons Attribution License.
