Paper Contents
Abstract
Blood is a fluid composed of living cells suspended in a non-cellular fluid matrix. Cellular components of blood are responsible for fuel exchange (red blood cells), immunity (white blood cells), and hemostatic responses (platelets), while non-cellular components (salt, protein, etc.) provide nutrients to various tissues. body. Blood transfusion is one of the most common procedures performed on patients in the hospital. Artificial blood is a product used to replace red blood cells. Although blood has many different functions, its main purpose is to carry oxygen and carbon dioxide throughout the body. The initial development of blood transfusion dates to the early 1600s, and the search for effective blood transfusion continues. Malfunction and deficiency of these blood products cause tissue damage and death. Therefore, transfusion of whole blood or its components is an important clinical point in the treatment of trauma, surgery, myelosuppression and congenital hematological disorders. Nanotechnology offers an exciting way to achieve this goal by using material engineering techniques to create synthetic and semi-synthetic red blood cell replacement for oxygen transport, platelet replacement for hemostasis, and white blood cells for the immune system. Therefore, there is a need to develop alternative methods that can transfer blood reliably and safely. This article will provide a comprehensive review of various methods for generating artificial hemocytes and a critical discussion of the successes and challenges of the current state-of-the-art in this field. However, a recently developed hemoglobin-based oxygen carrier has been promising in early clinical trials and has been granted "orphan drug" status by the FDA.
Copyright
Copyright © 2023 Shivam Arun Wagh . This is an open access article distributed under the Creative Commons Attribution License.
