Paper Contents
Abstract
The study investigates the potential use of benzothiazole derivatives as new anticonvulsant drugs, concentrating on their pharmacological mechanisms, effectiveness in seizure models, and therapeutic benefits compared to existing antiepileptic medications (AEDs). An exhaustive review of synthetic benzothiazole compounds was performed, integrating molecular docking, structure-activity relationship (SAR) analysis, and preclinical evaluations using maximal electroshock (MES) and subcutaneous pentylenetetrazol (scPTZ) models. Computational methods, such as virtual screening and pharmacophore modeling, were utilized to estimate binding affinities and neurochemical interactions. Benzothiazole derivatives showed significant anticonvulsant activity, with compounds 7a, 7f, and 8b demonstrating protective effects similar to phenytoin in MES assessments. Substituents that donate electrons (e.g., CH3, Cl) improved lipophilicity and efficacy. Investigations into the mechanisms revealed that GABAergic modulation, glutamate suppression, and ion channel stabilization are crucial pathways. The toxicity profiles were positive, with minimal neurotoxicity noted in chronic trials. Benzothiazoles offer a promising framework for the development of safer, multitarget AEDs that also provide neuroprotective advantages. Further clinical validation is needed to tackle refractory epilepsy and reduce side effects linked to traditional treatments.
Copyright
Copyright © 2025 Mr. V. Bharathraj. This is an open access article distributed under the Creative Commons Attribution License.
