Paper Contents
Abstract
Utilizing nano-sized zinc oxide (ZnO) as a recoverable catalyst, a sustainable and effective procedure was established for creating quinoline compounds. This approach involved a Friedlander synthesis, where 2-aminobenzophenone was combined with ketones that can form enols, using ethanol as a solvent, heated to 60C. Compared to traditional acid catalysis, this methodology offers advantages such as gentler reaction conditions, accelerated reaction times, and increased environmental friendliness. The nano ZnO exhibited strong catalytic performance, yielding products at levels of 7894% within a 3 to 5 hour window. The reaction effectively accommodated a diverse range of reactants, including those with electron-donating and electron-withdrawing functional groups. Due to the use of ethanol, an environmentally conscious solvent, and the ability to reuse the nano ZnO, this technique is considered a cost-effective and green alternative. In summary, this investigation highlights nano ZnO as a valuable catalyst for Friedlander quinoline formation, delivering a practical and ecologically sound route for producing biologically relevant quinoline derivatives.
Copyright
Copyright © 2025 Sanjay R. Pawar. This is an open access article distributed under the Creative Commons Attribution License.
