Paper Contents
Abstract
AbstractCuminum cyminum (cumin), a spice widely used in culinary traditions, has garnered attention for its potential medicinal properties, particularly in cancer prevention and treatment. This review explores the anticancer activities of cumin and its bioactive compounds, such as cuminaldehyde, terpenes, and flavonoids. Numerous in vitro and in vivo studies suggest that these compounds exhibit significant antineoplastic effects, including the inhibition of cancer cell proliferation, induction of apoptosis, and suppression of metastasis. The mechanisms underlying these effects involve modulation of various molecular pathways, such as the inhibition of NF-B and PI3KAkt signaling, and the upregulation of tumor suppressor genes. Furthermore, cumin's antioxidant properties contribute to its anticancer potential by neutralizing free radicals and reducing oxidative stress, which is a known contributor to carcinogenesis. While preclinical studies provide promising results, clinical trials are necessary to validate cumin's efficacy and safety in cancer therapy. Additionally, the review highlights the synergistic effects of cumin when used in combination with conventional chemotherapeutic agents, suggesting potential enhancements in treatment outcomes and reductions in drug toxicity. The findings underscore the need for further research to fully understand the therapeutic potential and application of cumin in oncology. This comprehensive review aims to provide a foundation for future studies and encourages the integration of cumin into cancer prevention and treatment strategies.Keywords Cumin, anticancer properties, Bioactive compounds, cuminaldehyde, apoptosis, NF-B, PI3KAkt, antioxidant, oxidative stress, chemoprevention, chemotherapeutic synergy.
Copyright
Copyright © 2024 Dr. Sanjay Kumar Acharya. This is an open access article distributed under the Creative Commons Attribution License.
