Recent Papers

ABSTRACTElectrochemotherapy (ECT) is a promising technique that combines chemotherapy with electroporation to enhance drug delivery to cancer cells. The development of a low-voltage electroporator offers significant advantages for improving the safety, accessibility, and efficiency of ECT. Traditional electroporators use high-voltage pulses to temporarily permeabilize cell membranes, allowing chemotherapeutic agents to penetrate more effectively. However, high-voltage systems can pose risks of collateral tissue damage and patient discomfort, limiting their clinical application. This study presents the design, construction, and testing of a low-voltage electroporator optimized for ECT. The system operates within a safer voltage range while maintaining sufficient electric field strength to induce reversible electroporation in targeted tumor cells. It employs precise pulse modulation techniques to achieve the required permeability with minimal adverse effects. The low-voltage design reduces the complexity of the device, making it more cost-effective and portable, suitable for use in outpatient settings and resource-limited environments. The electroporator was tested in preclinical models, where it demonstrated an improvement in the uptake of chemotherapeutic agents like bleomycin and cisplatin, leading to enhanced cytotoxic effects on tumor cells. Clinical potential was further assessed by evaluating patient comfort, reduction in adverse effects, and overall treatment efficacy. The study shows that the low-voltage electroporator significantly improves patient outcomes by reducing pain and side effects associated with high-voltage procedures. This development paves the way for broader adoption of ECT as a standard cancer therapy, especially in cases where conventional methods have failed or are unsuitable. Future work will focus on optimizing pulse parameters, integrating real-time feedback mechanisms, and conducting large-scale clinical trials to confirm its effectiveness in diverse patient populations.Keywords: Electroporator, Electropermeabilization, Epithelial Cell, Pulse Duration, Pulse Amplitude.

Copyright © 2024 Engr. D. M. Nazif. This is an open access article distributed under the Creative Commons Attribution License.