DRUG INDUCED HYPERSENSITIVITY SYNDROME WITH PANCYTOPENIA AND SEPSIS DUE TO PIPERACILLIN- TOZABACTUM AND MEROPENEM: A RARE CASE
Dr. Janavi G Janavi G
Paper Contents
Abstract
ABSTRACT:Dress response with systemic symptoms and eosinophilia (DRESS) is a rare adverse drug reaction that can be lethal. Visceral damage, dermatitis, and haematological abnormalities are possible outcomes of this sickness, which has a long latency period. Clinical signs and symptoms of DRESS might vary. We describe a 34-year-old female who presented with lethargy, giddiness, and severe monthly bleeding. The laboratory examination indicated pancytopenia with leukocytosis, a peripheral blood smear suggestive of blasts, and clinical symptoms consistent with acute Leukemia. The antibiotics used here are meropenem and piperacillintazobactam (PipTaz). As a result, both systemic and eosinophilic symptoms appeared. These symptoms were all connected to DRESS. After Ceftriaxone was administered and the sensitising drug was stopped, the symptoms gradually subsided. Physicians should be alert for indications of abnormal behaviour.
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Copyright © 2025 Dr. Janavi G. This is an open access article distributed under the Creative Commons Attribution License.