Paper Contents
Abstract
Depression disorder has significant potential morbidity and mortality, contributing to suicide, incidence and adverse outcomes of medical illness, disruption in interpersonal relationships, substance abuse, and lost work time. The present study was designed to study the anti-depressant activity of the leaves extract of Mimosa pudica using forced swim test and tail suspension test on Swiss albino Rats. The anti-depressant activity of the leaves of Mimosa pudica was assessed using Chronic Unpredictable Mild-Stress (CUMS) induced depression in Rats. The animals were treated with the ethanolic extract of leaves of Mimosa pudica orally at two doses of 100; 200mgkg body weight for eight days after CUMS induced depression in Rats. The results demonstrate that ethanolic extract of Mimosa pudica has got anti-depressant potential. The study showed that the extract of Mimosa pudica had significant antidepressant activity. The Microsoft excel was used to calculate the mean SEM and one way ANOVA followed by turkey multiple comparison test were used to analyzed the results. The extract presented significant antidepressant activity in Rats (p<0.05). This study was conducted to explore the antidepressant activity of leaves extracts of plant Mimosa pudica in CUMS induced Rats.
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