Paper Contents
Abstract
Objective: -To investigate the Nephroprotective activity of ethanol extract of Eurycoma Longifolia on Gentamicin induced Nephrotoxicity in male Wistar rats.Material & method: - In this model of Nephrotoxicity, 30 adult male wistar rats (150-200gms) were evenly divided into 5 groups. Group-1 and Group-2 served as untreated and model controls respectively, while Group-3, 4 and 5 were the treatments groups which were simultaneously treated with standard, 200 and 400 mgkg extract respectively, after each dose Gentamicin (80 mgkg, i.p.) for 10 day . On 11 th day, blood samples for biochemical parameters, while the rats kidneys for histology were obtained under inhaled diether anaesthesia.Results: - Gentamicin treatment caused Nephrotoxicity as evidenced by marked elevation in blood urea, uric acid and Creatinine. Co-administration of extract with Eurycoma Longifolia decreased rise in blood urea, uric acid and Creatinine. Apart from these, histopathological changes also showed the protective nature of extract against Gentamicin induced necrotic damage of renal tissues.Conclusion: - It was observed that the ethanol extract of conferred nephroprotective activity by histopathological and biochemical observation against Gentamicin induced Nephrotoxicity in rats. In the near future could constitute a lead to discovery of a novel drug for treatment of drug induced Nephrotoxicity.
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