Paper Contents
Abstract
Ethosomes entrapping ornidazole were prepared using cold method and the effect of varying concentration of ethanol was considered for obtaining an optimized formulation. Lecithin (2%ww) was used as the phospholipid to provide the structure to vesicles and propylene glycol (10%) was used as the permeating agent. The vesicles were found to be of spherical to irregular shape ranged from 3.596 0.855 m to 6.496 2.576 m in size. The drug entrapment in the ethosomes was studied by analyzing the amount of drug after breaking the vesicles with Triton X100 and it was found that the maximum entrapment efficiency was found to 94.11% for formulation F5 and minimum 87.18% for formulation F1, respectively. The in vitro release study suggested that the maximum amount of drug released from the ethosome was 98.1% for F1 while the least release was 89.7% from F5 in 12 h. It was observed that only about 1.18% degradation occurred at 25C and the formulation was almost stable at 4C with only 0.89% loss of the entrapped ornidazole thereby proving the stability of the developed system.
Copyright
Copyright © 2023 Rahul Kumar. This is an open access article distributed under the Creative Commons Attribution License.
