Paper Contents
Abstract
The kidney is a urinary organ that eliminates most toxic substances that are either ingested or produced by the body. The nephrotoxic actions are raised by aluminium (Al) metal and its accumulation in the kidneys. However, Al generates reactive oxygen species with the resultant degeneration of the renal tubular cells, the oxidative deterioration of cellular lipids, proteins, and DNA. The histopathological examination of the kidneys of aluminium- treated group rats revealed kidney injury with enlargement of many glomeruli, tubular dilatation, necrotic changes, and leukocytic infiltration. Several reports show that aluminium toxicity on kidneys occurs through dietary sources, even though its association with adverse effects such as dementia, osteomalacia, encephalopathy, and fractures. More recent ingestion of aluminium showed obvious signs of focal segmental thickening, renal corpuscle injury, podocyte changes, and mesangial cells appearing highly deteriorated. For the above reasons, this review was written to contribute to the role of aluminium metal toxicity, toxic mechanisms and toxic effects in the kidneys of rats.Keywords: Aluminium, histopathological examination, kidney, mesangial cells.
Copyright
Copyright © 2024 G. Kondaiah. This is an open access article distributed under the Creative Commons Attribution License.
