Paper Contents
Abstract
Dependency on alcohol has a negative impact on people's health and the economy and is a big global issue. Because of alcohol withdrawal, there is a relapse in alcohol consumption. The symptoms of alcohol withdrawal, which resemble anxiety, start to show 624 hours after the last alcohol consumption. The purpose of the current investigation was to determine whether a standardized polyherbal mixture could shield Wistar rats from the anxiety associated with ethanol withdrawal. Three plant extractsCymbopogon citratus, Cinnamomum tamala, and Urtica diocawere combined in a 1:1:1 ratio to create the polyherbal mixture. Using HPTLC, phytochemical profiling of the polyherbal formulation was conducted. With the use of a two-bottle choice drinking paradigm model that allowed animals to freely choose between alcohol and water for 15 days, researchers examined the impact of polyherbal preparations on alcohol withdrawal anxiety, sadness, and seizures. The 16th day was the withdrawal day for alcohol, during which time patients received treatment with Nutriley alquit powder (20 mgkg) and polyherbal preparation (10 and 30 mgkg, oral). Utilizing EPM, FST, and TST, behavioural characteristics were examined. Gallic acid, rutin, and quercetin are among the main phytoconstituents found in polyherbal preparations, according to phytochemical profiling. Polyherbal formulation has antidepressant and antianxiety benefits during alcohol withdrawal, according to in vivo investigations. The study comes to the conclusion that ethanol-type dependence may be treated therapeutically with polyherbal preparations.
Copyright
Copyright © 2024 Soham Chakrabarti. This is an open access article distributed under the Creative Commons Attribution License.
