Paper Contents
Abstract
The zebra fish has appeared as a suitable vertebrate model for examining liver related disorders. Liver impairment is a pivotal problem in the procedure of drug development. Zebra fish have demonstrated to be an essential tool in high throughput screening of drugs for hepatotoxicity. In spite of construction of zebra fish liver varies from mammals, the elementary physiological functions, genetic evolution and much resemblance. The major advantage of the zebra fish is the larval transparency which is helpful in hepatic studies by real time imaging. The bio conversion of drugs which includes oxidation, reduction has identical pathways as present in mammals due to the presence of cytochrome p450 enzymes. In the present review, the effects in the liver due to long term exposure to ethanol is evaluated.
Copyright
Copyright © 2023 Tharunkumar Sivasankar. This is an open access article distributed under the Creative Commons Attribution License.
