Paper Contents
Abstract
Dermatitis herpetiformis (DH) is a chronic, autoimmune blistering disorder of the skin, closely associated with celiac disease. It is characterized by intensely itchy, papulovesicular eruptions, typically on the elbows and knees.The primary feature of DH is intensely pruritic (itchy) lesions, which often appear as small, fluid-filled blisters or raised, red bumps, typically located on the extensor surfaces of the body. Diagnosis is confirmed by skin biopsy with direct immunofluorescence, revealing granular IgA deposits. The treatment of choice for DH includes a gluten-free diet, which addresses the underlying cause, and dapsone, a medication that effectively controls symptoms.DH results from an immune response to gluten, leading to the deposition of IgA antibodies in the skin's papillary dermis. The condition is genetically linked, with a higher prevalence in individuals carrying the HLA-DQ2 or HLA-DQ8 haplotypes
Copyright
Copyright © 2025 Dhiraj Prakash Bhoi. This is an open access article distributed under the Creative Commons Attribution License.
