Paper Contents
Abstract
AbstractVitis quadrangularis, known in Ayurveda as Asthisamharaka, is a perennial plant with a rich history of use in traditional medicine for skeletal and metabolic disorders. This review aims to provide a comprehensive synthesis of its traditional Ayurvedic applications and to critically evaluate the modern scientific evidence supporting its therapeutic potential. A systematic literature search was conducted across classical Ayurvedic texts and modern scientific databases, including PubMed, Scopus, and Google Scholar, to collate information on the plant's botany, phytochemistry, and pharmacology. In Ayurveda, Asthisamharaka is primarily indicated for Asthibhagna (bone fracture) and Sandhigatavata (osteoarthritis), an application directly reflected in its name, which translates to "bone setter." Phytochemical analysis reveals a rich profile of bioactive compounds, including ketosteroids, triterpenoids, flavonoids, and stilbenes, which are believed to underpin its medicinal properties. Preclinical studies robustly demonstrate its osteogenic and anti-osteoporotic effects, showing that its extracts enhance osteoblast proliferation and mineralization, inhibit osteoclastogenesis, and modulate key signaling pathways and cytokine profiles. Clinical trials in humans have validated its efficacy in accelerating fracture healing, reducing joint pain, and managing weight and metabolic syndrome parameters. While its effect on established osteoporosis is more focused on slowing bone loss than rebuilding bone mineral concludes that there is a strong correlation between the traditional Ayurvedic uses of Asthisamharaka and its scientifically validated pharmacological activities, particularly in bone health. Further high-quality, long-term clinical trials are warranted to fully integrate this potent Ayurvedic remedy into evidence-based clinical practice.
Copyright
Copyright © 2025 Dr.Sandhya Maravi. This is an open access article distributed under the Creative Commons Attribution License.
