Paper Contents
Abstract
Tinospora cordifolia generally known Giloy, has been ranked as one of the most important herbs for eliminating diseases in Ayurvedic system of medicine. Over the last decade, scientific investigations have directed their interest towards the possible curative effect of this component in the management of diabetes and allied metabolic complications. Accordingly, this paper examines the plausible actions through which Tinospora cordifolia possibly elicits it anti-diabetic effects in relation to glycemic control, insulin sensitivity, and oxidative stress. Pharmacologically active compounds of Tinospora cordifolia are alkaloids, glycosides and polysaccharides that directly contribute the activity of it. Scientific documents available on the effects of Tinospora cordifolia revealed that the factor acts by stimulating insulin in the organism, reducing hepatic glucose production, and improving glucose assimilation by the peripheral tissues. In addition, antioxidant activity of TGR has the ability to prevent oxidative stress that results from high glucose levels. Clinical trials have shown this and declared the above facts claiming that it has some efficacy to lower HbA1c and to enhance lipid profiles among diabetic population. Anti-oxidant and anti-inflammatory potential of Tinospora cordifolia was further supported and attributed to the improvement of the metabolic disorders. However, it should be noted that systematic and more large-scaled clinical trials should be performed to confirm its effects and safety for the long-term treatment of diabetes. This review is therefore aimed at providing an integrated perception of the part played by Tinospora cordifolia in the domain of diabetes with an eye on the appropriateness of this plant species as a supplemental remedy for diabetes and its correlates. Keywords: Guduchi, diabetes, metabolic syndrome, insulin sensitivity, oxidative stress, anti-inflammatory, immunomodulatory, clinical studies.
Copyright
Copyright © 2024 Dr. Sanjay Kumar Acharya. This is an open access article distributed under the Creative Commons Attribution License.
